Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Glycoconjugate Biosynthesis Biosynthesis and functions of 0-glycans and regulation of mucin antigen expression in cancer

Secreted mucins and cell-surface mucin-type common 0-glycan core structures can be syntheglycoproteins are rich in 0-glycans and are often sized (Figure 1). Core 1 is the precursor strucresponsible for the expression of biologically ture for the synthesis of core 2, and core 3 is the important ligands and cancer-associated epiprecursor for core 4 [2]. All four common core topes. These epitopes ...

متن کامل

Size-dependent protein segregation at membrane interfaces.

Membrane interfaces formed at cell-cell junctions are associated with characteristic patterns of membrane protein organization, such as E-cadherin enrichment in epithelial junctional complexes and CD45 exclusion from the signaling foci of immunological synapses. To isolate the role of protein size in these processes, we reconstituted membrane interfaces in vitro using giant unilamellar vesicles...

متن کامل

Emerging structural themes in large RNA molecules.

Extensive networks of tertiary interactions give rise to unique, highly organized domain architectures that characterize the three-dimensional structure of large RNA molecules. Formed by stacked layers of a near-planar arrangement of contiguous coaxial helices, large RNA molecules are relatively flat in overall shape. The functional core of these molecules is stabilized by a diverse set of tert...

متن کامل

Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

Leishmaniases are a set of tropical and sub-tropical diseases caused by protozoan parasites of the genus Leishmania whose severity ranges from self-healing cutaneous lesions to fatal visceral infections. Leishmania parasites synthesise a wide array of cell surface and secreted glycoconjugates that play important roles in infection. These glycoconjugates are particularly abundant in the promasti...

متن کامل

Common mechanistic themes for the powerstroke of kinesin-14 motors.

Kar3Cik1 is a heterodimeric kinesin-14 from Saccharomyces cerevisiae involved in spindle formation during mitosis and karyogamy in mating cells. Kar3 represents a canonical kinesin motor domain that interacts with microtubules under the control of ATP-hydrolysis. In vivo, the localization and function of Kar3 is differentially regulated by its interacting stoichiometrically with either Cik1 or ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Current Opinion in Structural Biology

سال: 2019

ISSN: 0959-440X

DOI: 10.1016/j.sbi.2019.03.013